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In this model, the combination of IKE and 5-FU produced a greater reduction in tumor size than 5-FU alone

doi:10.1016/j.cmet.2008.07.005

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Cereblon is the substrate-binding component of the E3 protein ligase complex DDB1 (damage specific DNA binding protein 1)-CUL4A (cullin 4)-RBX1 (ring-box 1), which is involved in the ubiquitination and proteasomal degradation of target proteins

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The resulting oxidative stress impairs mitochondrial respiration, compromises ETC function, and increases membrane permeability, resulting in reduced ATP production and potential mitochondrial shutdown [97, 98]