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In septic ICU patients with elevated lactate, treatment with vitamin C and thiamine lowered hospital mortality, showing the strongest benefit when both were given together, especially in vasopressor-dependent cases (Marik et al., 2017)

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N-Hcy-Lys, Cys, Hcy and GSH react quantitatively in plasma in the presence of a slightly alkaline buffer to give corresponding 2-pyridinium derivatives

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