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The smoking-associated chronic inflammation could induce squamous metaplasia and facilitate oncogenesis and metastasis based on the accumulation of genetic changes such as TP53 and AKR1B10 [30,31,32,33]

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[DOI] [PubMed] [Google Scholar] 499.Xu C., Qiao L., Ma L., Yan S., Guo Y., Dou X., Zhang B., Roman A

During this process, NADPH oxidase was activated and upregulated

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