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doi: 10.1542/peds.111.3.477 46

Chapter 8 - inflammatory and oxidative stress markers in skeletal muscle of obese subjects

Although the precise molecular mechanisms remain largely elusive, we will describe how ceramides target mitochondria function in brain by several mechanisms: (1) changes in the lipid composition of the mitochondria membrane, (2) alteration in mitochondrial respiratory chain activity and increased in ROS production, and (3) changes in mitophagyapoptosis process

It has also been shown that 100 mg LA/kg body weight/day, i.p., for 2 weeks [38], which is equivalent to 510 g LA/day in humansincreases oxidative damage in elderly rats

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