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No IGF-1 analogue, including LR3, holds FDA approval for adult use, body composition, or athletic performance [15]

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Montalban-Bravo G, Bose P, Alvarado Y, Daver N, Ravandi F, Borthakur G, Takahashi K, Andreeff M , Cortes JE, DiNardo CD, Jabbour E, Kadia TM, Kornblau SM, Ohanian M, Pierola AA, Huang X, Nogueras-Gonzalez GM, Bodden K, Littles K, Pierce S, Bueso-Ramos CE, Kantarjian H, Garcia-Manero G

They are naturally occurring in the body, signalling molecules that dictate major physiological processes like tissue repair or metabolism

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However, the gshF copy number increase didnt further improve GSH concentration in W303-1b/F, indicating that a reasonable rather than high copy number of gshF gene driven by GAP promoter is sufficient for the highest expression levels and synthetic capacity of GSH through one pathway is limited