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Currently, different groups are developing methods to overcome these issues based on the incorporation of vascular endothelial growth factor (VEGF) and WNT7b or co-culture methods with mesodermal progenitors generating a vascular networks (Shi et al., 2020

Individuals with liver or kidney conditions

Coenzyme Q10 (CoQ10), in addition to its antioxidative role, contributes to mitochondrial membrane potential stabilization, improving GPX4 efficiency within mitochondrial membranes (Zhao et al., 2021

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More specifically, melatonin blocks ROS/RNS pathways, thus mitigating oxidative stress and damage to the cells, preventing mitochondrial fission and encouraging mitochondrial fusion, blocking the release of mitochondrial DNA, and preventing mitophagy, which is the phagocytosis of mitochondria

As a result, menopausal syndrome has a profound effect on womens quality of life (Sultana et al., 2023)