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In its absence, Teff cells become sensitive to conjugated BAs (CBAs), leading to oxidative stress and elevated production of pro-inflammatory cytokines like IFN- and TNF-

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The second step in glutathione (GSH) synthesis is catalyzed by the enzyme Glutathione Synthase (GS, EC 6.3.2.3, formerly known as GSH synthetase)

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In rare cases the oral administration can be followed by shortness of breath, upset stomach and bronchospasm