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the enzyme's activity responds to sustained suppression over days and weeks, not single-dose precision

Concentrated solutions (10 mg/mL) require smaller injection volumes, which can be challenging to measure accurately with standard syringes

ATP production is dependent on the return of the protons accumulated in the intermembrane space to the matrix through the F O portion of the ATP synthase, inducing the rotation of the subunit of the F 1 portion [31]

This doesn't mean they're dangerous or ineffective, but it does mean: Limited clinical data: Without the trials required for approval, human data remains sparse

Injecting a solution contaminated with bacteria can lead to localized infections, abscesses, or even systemic immune responses