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E2 deficiency downregulates the Er-PGC-1-NRF1 transcriptional axis, leading to suppressed SOD2 expression and impaired clearance of mitochondrial ROS, initiating a vicious cycle of oxidative damage and mitochondrial destabilization (122)

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Vitamin D is very Guidelines for blood levels of vitamin D from Sufficient: 2050 nanograms per milliliter (ng/mL), or 50125 nanomoles per liter (nmol/L) Safe upper limit: 50 ng/mL, or 125 nmol/L Toxic: above 5060 ng/mL, or above 125150 nmol/L There is some disagreement on how much vitamin D is optimal for health

The cells treated with Sp showed slight enhancement in levels of GSH (~1.2 fold), together with minor alterations in GSSG levels, compared to untreated samples which exhibited higher GSSG content, thus indicating efficient recycling of GSSG to GSH (Fig