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Mattson, 2004)

Research indicates that NNMT expression correlates positively with insulin resistance, with plasma levels of the NNMT product 1-methylnicotinamide associated with increased body mass index and metabolic dysfunction

That basically means no one knows whether the vitamin helps or hurts, or even if deficiencies increase your risk

For every 5 umol/L increase in plasma homocysteine, there was a 20% increase in the risk of coronary heart disease.22 These findings were confirmed by another review of 35 studies conducted in 14 countries among 27,448 adults and children aged 5 to 60 years

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