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There are a couple of other scenarios in which acetaminophen is more likely to cause liver damage: Alcohol Use Disorder: Normally, alcohol is metabolized using the alcohol dehydrogenase enzymes, but in cases of chronic overconsumption or binge drinking, the CYP2E1 enzyme is upregulated to metabolize the extra alcohol

Biomaterials 125, 3853

There is a notable exception that relates to acute glutathione depletion due to acetaminophen (paracetamol) overdose, as we shall see

aureus strains at MOI 1020 via centrifugation at 1,000 g for 2 min, followed by 35 min incubation at 37 C

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& Etlinger, J