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Because the cohesin loader is enriched at polyA tracts 13 , we asked whether it preferentially interacts with or activates RSC1

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Three sections containing the hippocampus (between 1.82 and 2.3 mm relative to the bregma) were stained for microglial Iba-1 or astrocytic GFAP, as described before [4] and using antibodies as detailed in Supplementary Table 2, diluted in 20% normal goat serum

Without effective Phase 3 clearance, even well-functioning Phase 1 and Phase 2 pathways can result in toxin recirculation and symptom exacerbation