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doi: 10.1126/scitranslmed.abq1533 60 GuoY.LuoR.WangY.DengP.SongT.ZhangM.et al

Zn, Zinc

Mechanistically, p53 decreases the monoubiquitination rate of histone H2B on lysine 120 (H2Bub1) in the SLC7A11 gene regulatory region by facilitating the nuclear translocation of the deubiquitinase USP7, leading to the inactivation of SLC7A11 expression in erastin-treated cells [122]

Int J Mol Sci 2020;21

Moreover, the increased axonal regeneration and myelination observed in the treated groups was accompanied by enhanced levels of BDNF, an activation of Akt, and subsequently increased levels of p-mTORC1 and p-GSK3, which are all key players in axonal regeneration signaling cascades [62]