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DOI: 10.1016/S0149-7634(99)00041-X 24

PLs are an endogenous defense factor that protects the skin from oxidative stress and are in a high concentration in the skin

However, a post hoc analysis revealed a potential beneficial effect of NAC in a subgroup of individuals carrying a specific genetic variant, TOLLIP rs3750920 TT genotype, present in about 25% of patients with IPF

recently showed that direct GPx4 overexpression in the cellular models (A549, H460 and H1299 and H23) of non-small cell lung carcinoma (NSCLC) prevented the radiation-induced lipid peroxidation and, in turn, contributed to radioresistance by blocking the ferroptosis mode of cell death [56]

However, NAC administration was not effective in blocking the phosgene-induced increase in tracheal pressure