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AGE-RAGE interaction has also been known to induce apoptosis (third pathway) and neuroinflammation (fourth pathway) via upregulation of p38 MAPK and activation of NF-B, respectively

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doi: 10.1038/s41574-019-0184-8 29 Grijota-MartinezCBarez-LopezSGomez-AndresDGuadano-FerrazA

Prostanoid receptor antagonists: development strategies and therapeutic applications

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153 Additional psychological therapies increase the effectiveness of gradual dose reduction, particularly in patients with insomnia and panic disorder