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Ce mdicament ne doit pas tre utilis si vous avez une maladie hrditaire entranant un mauvais fonctionnement du nerf optique et se manifestant par une baisse brutale de la vision, appele neuropathie optique hrditaire de Leber, car il existe un risque accru datrophie optique (destruction des fibres du nerf optique) potentiellement rapide et svre

fda.gov/regulatory-information/search-fda-guidance-documents/q14-analytical-procedure-development National Institute of Standards and Technology

Data derived from laboratory toxicity tests have been used in developing and also validating models to predict biological effects, using mechanistic studies of single hydrocarbons, which are then validated using both hydrocarbon mixture and whole oil exposure tests (e.g., French-McCay, 2002)

At higher doses, you need multiple draws and multiple injection sites

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