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For some people, the answer is yes, though it is usually temporary and often related to the specific form of the supplement

Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action

Traditionally, people and animals got B12 from eating food from the ground and drinking non-treated water but with so many farmed animals now confined in factory farms, they are fed B12 supplements

So if its been identified via a blood test (through a health professional) and your doctor recommends injections, it is important to get those B12 levels up

Premedication with folic acid, vitamin B12, and dexamethasone helps reduce toxicity

Additionally, MMP-2 is frequently implicated in cardiac pathologies (69), a common outcome in those diagnosed with PTSD (70)