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Centers for Disease Control and Prevention (CDC) has established blood lead reference values of 3.5 g/dl for children and 5 g/dl for adults, with the 2021 update revising the reference value from 5 g/dl to 3.5 g/dl ( SDI The SDI is a comprehensive metric for evaluating the socioeconomic development of a country or region ( Bayesian age-period-cohort (BAPC) analysis The BAPC model is a methodological approach employed in epidemiology and biostatistics to analyze the temporal trends of mortality and DALYs associated with AF/AFL due to lead exposure

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98,99,100 Under oxidative stress conditions, ROS may also interfere with mtDNA replication and repair mechanism

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