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Mazade MA, Edwards MS

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Both GRXS14 and GRXS16 were able to complement the growth defects of yeast grx5 mutant, suggesting that these two proteins are functional GRXs (Bandyopadhyay et al., 2) and the binding is assisted by the Cys residues of two glutathione molecules (Bandyopadhyay et al., in vitro 2Fe-2S cluster assembly and the 2Fe-2S cluster in GRXS14 could be readily transferred to apo Fd (Figure 4A) (Bandyopadhyay et al., in vivo delivery of 2Fe-2S to recipient proteins (Figure 4C) (Mapolelo et al., 2013)

In particular, NAD+ plays an auxiliary substrate function in the deacylation reaction of the SIRTs family

More detail on this link between homocysteine and dementia is explored in greater depth