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Likewise, methods used to assess mtDNA mutations and deletionsincluding long-range PCR, NGS, and targeted mitochondrial arraysvary widely in their ability to detect low heteroplasmy or large structural variants (131133)

10.1161/CIRCRESAHA.113.301241 201

6 Discussion Synthesizing the foregoing evidence, this article proposes a central hypothesis of ferroptosis in periodontitis: ferroptosis is not merely a passive accompaniment to disease progression, but has the potential to evolve into an important node and signal amplification link within the pathological network