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Salicylic acid is a beta-hydroxy acid (BHA) derived from willow bark

101 In addition, hypoxia-induced lactylation of serine hydroxymethyltransferase 2 (SHMT2) upregulates its protein level, enhancing methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) expression and the stemness of esophageal squamous cell carcinoma cell lines, thus accelerating the malignant progression of esophageal cancer

The interaction between the host genome, epigenome, and the gut-skin axis microbiome in atopic dermatitis

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Although the dissociated YRS played a pro-tumorigenic role, another study claimed that upregulated YRS translocated from the cytosol to the nucleus to protect the DNA against oxidative stress-induced damage (Wei et al., 2014)

Preclinical wound healing Animal wound-healing studies in rats, mice, rabbits, and pigs reported faster wound contraction, increased collagen, and improved angiogenesis with GHK-Cu, including systemic effects when GHK-Cu was injected at one site and improved healing at distant sites