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Inhalation avoids hepatic first-pass metabolism and the lungs have lower enzymatic activity than other organs [97]

Grajchen E, Loix M, Baeten P, Crte-Real BF, Hamad I, Vanherle S, et al

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271 Cys102 and Cys153 in HDAC8 are integral to its redox switch, with disulfide bond formation under oxidative conditions potentially resulting in reversible enzyme activity loss

doi: 10.1016/j.jare.2025.03.026