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In vivo validation of hits using retroductal injection Based upon drug down selection data and measured EC 50 values, Phenylbutazone, Enoxacin, and Doripenem hydrate were selected for in vivo validation in mice using H2AX foci per nucleus IHC staining as an outcome measure consistent with prior work showing correlation with the development of xerostomia (Supplementary Fig

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Typically, this condition appears like a single stripe of blisters that wraps around the left side or the right side of the torso

10.1093/toxsci/kfp190 81 LeBaronH

1 (download XLSX Statistical source data for Fig