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Description

Sevoz C, Rousselle C, Benot E, Buronfosse T

10.1128/IAI.72.7.4023-4030.2004 166

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Additionally, TQ phosphorylated JNK and the extracellular signal-regulated kinase (ERK), causing MAPK to initiate apoptosis

Its stability is critically compromised under physiological pH (7.4), where it undergoes rapid alkaline hydrolysis through nucleophilic attack on the ,-unsaturated -diketone moiety