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Furthermore, this focus is due to the kidneys critical role in metabolizing and eliminating AA from the human system [63,64,65]

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DNA sensing by the cGAS-STING pathway in health and disease

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tFNA-treated models, compared to untreated AIS models, have been shown to have preserved neurons and, to some extent, enhanced neurogenesis, which shows a promising ability for neuroprotection and regeneration potential in the tFNAs 49

This pertains for instance to the updated OECD guideline for 28-day oral toxicity testing (Koeter, 1995)