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Notably, active mTORC1-S6K1 signaling forms a negative feedback loop in the GF signaling pathway, through an S6K1-dependent inhibitory phosphorylation event on IRS-1 (insulin receptor substrate 1), which is important for fine-tuning the cellular response to GF and in the development of resistance to mTOR inhibitors (Harrington et al., 2004

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[Google Scholar] 63.Seo H., Oh H., Park H., Park M., Jang Y., Lee M

The alpha-synuclein SAAs, using CSF or more accessible fluids such as plasma, are likely to be important in stratification for trials and for targeted treatment, with potential for monitoring disease progression as quantification metrics become more reproducible