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Bone fracture incidence after androgen deprivation therapy-investigational agents: results from cancer therapy evaluation program-sponsored early phase clinical trials 2006-2013

identified in TP53 mutant cell lines, in vivo models, and primary patient samples that the combination of APR-246 and azacitidine results in a synergistic pro-apoptotic effect as well as a dramatic reduction in cell proliferation via cell cycle arrest (Figure 1)

This can be an interesting topic for the vegetable/fruit processed food industry, as it reveals the need to further comprehend how to correctly apply the polyphenols potential and how the polyphenoldietary fibre matrix controls the polyphenols release rate and their behaviour during digestion

No exact-name ClinicalTrials.gov record was located in the July 12, 2026 search, and this review did not establish human benefits, safety, pharmacokinetics, or a clinical formulation

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