This is especially important for people at risk for multiple deficiencies, including those with GI conditions, a history of gastric bypass surgery, impaired kidney function, older adults, and people taking PPIs
Moreover, emerging technologies such as targeted protein/RNA degradation methods (e.g., LYTAC, ATTEC), as well as novel approaches targeting cell substructures (exosomes, lysosomes), nuclear export pathways, the cell membrane, and RNA molecules, offer promising opportunities for advancing medicinal chemistry
Cancer Lett 234:3439 Holzer AK, Manorek GH, Howell SB (2006) Contribution of the major copper influx transporter CTR1 to the cellular accumulation of cisplatin, carboplatin, and oxaliplatin
Peng F, Tang H, Liu P, Shen J, Guan X, Xie X, Gao J, Xiong L, Jia L, Chen J, et al
Notably, the lower weight loss (-13.7%) observed in REDEFINE 2 among individuals with T2D suggests that the magnitude of benefit achieved with combined GLP-1 and amylin receptor agonism may depend on the underlying metabolic status, highlighting the need for a more nuanced understanding of the mechanisms governing treatment response [13]
Bioengineering devices that can reflect [native] tissue scaffolding and integration with other cell types would be a wonderful thing. We go to the grocery store, buy some asparagus, and use a biopsy punch to [create] cylinders of asparagus tissue