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Hum Reprod Update 18:525535 Morita Y, Perez GI, Paris F, Miranda SR, Ehleiter D, Haimovitz-Friedman A, Fuks Z, Xie Z, Reed JC, Schuchman EH et al (2000) Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

As microbiome research progresses, a deeper understanding of its complex interactions with the immune system and other physiological processes will pave the way for more targeted, personalized microbiome-based treatments, which may eventually complement or replace conventional therapies for gastrointestinal diseases

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7,8 Clinical management largely comprises surgical resection, and no effective pharmacological agent is yet available for effective treatment or cure, although some agents have shown promising results in preclinical or clinical trials, and will be discussed in detail in this review

Remodeling oncogenic transcriptomes by small molecules targeting NONO