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But only the R-isomer (R-ALA) is naturally produced in the body and actively participates in mitochondrial energy metabolism.12 Some studies suggest that R-ALA may be more bioavailable than standard racemic ALA though the clinical significance of this difference is still under investigation.17 In addition, anecdotal reports and small studies indicate that R-ALA may be easier on digestion, with fewer gastrointestinal side effects than standard racemic ALA, especially at higher doses.18 However, R-ALA is chemically unstable on its own

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10.1016/j.redox.2013.10.011 197 SanoH.SudoT.YokodeM.MurayamaT.KataokaH.TakakuraN.et al (2001)

A critical manifestation of this gap is the decline in inoculant viability over timefor example, a 40% reduction in Pseudomonas fluorescens population 12 months after field application 31