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The activated iodine binds to tyrosine residues on thyroglobulin molecules under the action of TPO to produce monoiodotyrosine (MIT) and diiodotyrosine (DIT), which are subsequently coupled to produce T3 or T4 ( Figure 1 )

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SN38-glu-Mal accumulated more at the tumor site than irinotecan, with its concentration in tumor tissue 30 times higher after 48 h

Angiogenesis 2014;17:471-94

Integration of a radiation biomarker into modeling of thyroid carcinogenesis and post-Chernobyl risk assessment