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It directly quenches reactive hydroxyl free radicals, other oxygen-centered free radicals, and radical centers on DNA and other biomolecules

[DOI] [PubMed] [Google Scholar] 50.Liu X, Zhang W, Wu Z, Yang Y, Kang YJ

These results suggest that the metformin-induced increase in glucose homeostasis was abolished by inhibition of GLUT1 expression, particularly in the distal intestine

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Notably, only a few studies have directly assessed analgesia as a primary outcome