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DOI: 10.1044/2020_AJSLP-19-00209 71

Common types of hyperpigmentation on the face include: Melasma Common areas: cheeks, upper lip, and forehead Triggers: sun exposure, pregnancy, and hormonal factors, including oral contraceptive pills Freckles and sunspots Common areas: can occur anywhere on the face Triggers: sun exposure Maturational hyperpigmentation Common areas: sides of the face Triggers: aging, sun exposure, genetic influences, and metabolic disease Periorbital hyperpigmentation Common areas: upper and lower eyelids Triggers: sun exposure, genetic factors, certain drugs, and hormonal causes Post-inflammatory hyperpigmentation Common areas: can occur anywhere on the face, but if due to acne, more common on the cheeks, chin, and forehead Triggers: acne, sun burns, skin rashes Home remedies to combat hyperpigmentation Topical therapies (creams and lotions applied to the skin) are the most common treatment option for hyperpigmentation

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Preclinical studies often require different dosing amounts depending on the administration route

When this happens, low levels of intrinsic factor produce symptoms of juvenile pernicious anemia in patients younger than age 10

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