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MOTS-c# Evidence Level: Preclinical | FDA Status: Category 2

64 SileikyteJ.Blachly-DysonE.SewellR.CarpiA.MenaboR.Di LisaF.et al (2014)

*Correspondence: Pedro Grandes, [email protected] These authors have contributed equally to this work and share last authorship This article was submitted to Nutrition, Psychology and Brain Health, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This has been reported as a major resistance mechanism against cDDP in several types of cancer [64, 65] and is believed to justify cell death when repairs are not possible [66]

[35] Mitochondrial DNA is replicated by the DNA polymerase gamma complex which is composed of a 140 kDa catalytic DNA polymerase encoded by the POLG gene and two 55 kDa accessory subunits encoded by the POLG2 gene

NNMT (nicotinamide N-methyltransferase) is a cytosolic enzyme that catalyzes a specific methylation reaction: it transfers a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing two products 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)