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Bitter and sweet taste receptors regulate human upper respiratory innate immunity

Ziegler RG, Fuhrman BJ, Moore SC, Mattews CE

In these contexts, astrocytes may shift from a neuroprotective role to one that exacerbates neuronal dysfunction, potentially due to downregulated expression of lactate dehydrogenase A (LDHA), a key glycolytic enzyme, which impairs lactate shuttling by inhibiting large conductance Ca 2+ activated potassium channel (BK channel)-mediated neuronal hyperpolarization (Yao et al., 2023)

Enhances the effectiveness of other antioxidants like vitamins C and E

6d and 9c,f

These reactions are a continuous persistent source of potentially cytotoxic Reactive Oxygen Species(ROS)