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While not entirely comprehensive and lacking robust evidence, this hypothesis has spurred significant research in the field

The most extensively studied areas include the accelerated healing of musculoskeletal tissues like tendons, ligaments, and muscles, as well as its protective and reparative effects on the gastrointestinal tract

Further studies have shown that due to heme-induced mitochondrial oxidative stress, the present ALAS2 transgenic mice has exhibited an increase in heme accumulation, aggravation of cell death, and exacerbation of cardiac dysfunction after coronary ligation compared with the control littermates (Sawicki et al., 2015b)

Among the members of this family, aldose reductase, the AKR1B gene product, has been the most extensively studied because it is intimately involved in diabetic complications [27]

Thus, intravenous N-acetylcysteine (NAC) is the antidote for APAP overdose given in Emergency Departments