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Product glucuronides are exported from hepatocytes by MRP2 (canalicular, into bile) and MRP3/MRP4 (basolateral, into blood for renal excretion)

Jacobson T, Maki K, Orringer C, Jones P, Kris-Etherton P, Sikand G, Forge R, Daniels S, Wilson D, Morris P, Wild R, Grundy S, Daviglus M, Ferdinand K, Vijay K, Deedwania P, Aberg J, Liao K, McKenney J, Ross J, Braun L, Ito M, Bolick J, Dicklin M, Kirkpatrick C, Rhodes K, Smith N, Blackett P, DeFerranti S, Gidding S, Davey R-E, McCrindle B, McNeal C, Urbina E, Dayspring T, Underberg J, Lopez J, Pirzada A, Roderguez C, Fichtenbaum C, Gallant J, Horberg M, Longenecker C, Myerson M, Overton E, Coblyn J, Curtis J, Plutzky J, Solomon D, Bays H, Brown W

discard if cloudy or particulate Dosing Calculation Example: If reconstituting 5 mg with 2.5 mL bacteriostatic water, the concentration is 2 mg/mL (2000 mcg/mL)

Y.ZhengR.ChenC.ChenY.LiuQ.et al (2017)

The synergistic and toxicitylowering effects of AC as an adjuvant to oxaliplatin in HCC therapy was also recently highlighted

Braz J Med Biol Res 25(2):129134 Grosso LM, Bracken MB (2005) Caffeine metabolism, genetics, and perinatal outcomes: a review of exposure assessment considerations during pregnancy