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K.ZyweaS.MahdiA.et al (2017)

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A study (72) assessing the effects of resveratrol on metabolic parameters in ob/ob mice injected daily with resveratrol for 20 days or left untreated (as controls) showed that resveratrol: reduces testosterone reduces insulin levels reduced TNF- and IL-6 levels in adipose tissue In a rat model for PCOS (73), daily intraperitoneal injection of resveratrol for 4 weeks induced: a significant reduction in the number of antral follicle counts a significantly decreased plasma anti-Mullerian hormone and insulin-like growth factor 1 levels (playing a key role in PCOS metabolic disturbances) significantly lower superoxide dismutase activity significantly increased glutathione peroxidase which will reduce cell vulnerability to ROS

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injection of 160 mg/kg tamoxifen for five consecutive days, as previously described 33 ) to induce Cre recombinase activity and Gclc excision (Fig