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Signalling mechanisms and cellular functions of SUMO

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After its synthesis, GSH is delivered to some intracellular compartments, including mitochondria, endoplasmic reticulum, nucleus, and to the extracellular space (e.g., blood plasma and bile) for utilization by other cells and tissues (Forman et al., 2009)

To overcome limited access to affected organs, transcriptomic reporter cell assays using patient plasma or serum to induce gene expression in a reporter cell population have been used as non-invasive tools to predict and understand a variety of diseases 34,35,36,37

It's deeper than the subcutaneous layer of skin