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The source of ROS in exercising muscle is easy to conjecture, as increased O 2 demand during exercise leads to enhanced mitochondrial generation of ROS

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The DDR triggered by shortened telomeres leads to a halt in cell growth, during which the cell endeavors to mend the inflicted harm

Chronic inflammation has been associated with the development of malignancy in several other organs such as the oesophagus, stomach, colon, liver and urinary bladder

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