glutathione spectroscopy Quantitative real-time imaging of Behavior of glutathione as ligand

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36 Consistent with this, one more research confirmed that IL-12 selectively induced the phosphorylation of STAT4 in T-bet + CD8 T cells, 39 and hence it can be inferred that genetic factor, antigen load and transcriptional factors including T-bet, as well as cytokine pathways such as IL-12, all contribute to the partial recovery of the function of exhausted T cells