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No controlled human trials have studied the combination

Demonstrated that administration of NMN, an NAD + precursor, markedly reduced subcutaneous fat mass in mice fed a high-fat diet (HFD)

Updated reports will be posted here once finalized

As shown in Table 1 and Figure 6, the small molecule inhibitors targeting NNMT can be categorized into SAM-competitive inhibitors, NAM-competitive inhibitors, Dual-substrate-competitive inhibitors and isomerization inhibitors

In further embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations chosen from Tables 1, 2, 3a, and 3b

No placebo-controlled human trial was identified for weight management, diabetes, fatty liver disease, sarcopenia, athletic performance or healthy ageing