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10.1002/adhm.202401613 111

FIGURE 1 3.1.1.3 Cancer metastasis and ROS Excessive level of ROS leads to metastasis via the stimulation of mitogen-activated protein kinase (MAPK), and phosphoinositide-3-kinase regulatory subunit/AKT serine/threonine kinases/mechanistic target of rapamycin kinase (PI2K/Akt/mTOR) signaling pathways that directs the activation of downstream metalloproteinase 9 (MMP9), metalloproteinase 2 (MMP2), SNAIL enzymes which initiate epithelial-mesenchymal transition (EMT) to metastasis (Kashyap et al., 2019)

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The relationship between the gut microbiota and thyroid disorders

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Ann N Y Acad Sci 2008;1127:92-100 DHooghe TM, Debrock S, Hill JA, Meuleman C