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This paper found that KEAP1-mutant tumours are sensitive to oxPPP inhibition

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doi: 10.1056/NEJMra1011040 20

Knockdown of amphiregulin triggers doxorubicin-induced autophagic and apoptotic death by regulating endoplasmic reticulum stress in glioblastoma cells

This intensity gated systemic redox signaling model is illustrated in Figure 6, where the signal is released into the blood stream in response to the high intensity exercise and activates Nrf2 signaling in the contralateral unstimulated muscle, while low intensity muscle stimulation does not meet the threshold to propagate a systemic redox signaling response

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