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Dupilumab, an IL-4R monoclonal antibody, demonstrates the clinical impact of IL-4R-triggered pathways in severe Th2-high asthma [53, 54]

Notably, semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist originally developed for T2DM and obesity, has shown robust efficacy in achieving resolution of steatohepatitis, underscoring its potential for repurposing in MASLD management [94]