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This effect was confined to the mitochondrial matrix, as the cytosolic glutathione pool was not affected by CHCHD2 KO (Fig

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The differential regulation on these genes may be due to several factors

Clinical research implications: brain mechanisms, brain biomarkers, and brain-based interventions First, regarding brain mechanisms, out of the four common themes we identified, only one of those has been investigated in humans (hyperactivity), and the remaining themes should be studied to gain a better understanding of the role of the human brain in CIPN

After three PBS washes, cells were blocked with 0.5% BSA in PBS, and incubated with the anti-SLC25A39 (Proteintech, 14693-1-AP, 1:200) and anti-ATP5A (Thermo Fisher Scientific, 439800, 1:200) primary antibodies in blocking solution for one hour