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Pharmacological therapies targeting GPX4 are a promising strategy for inducing ferroptosis in cancer cells, including clear-cell carcinomas that resistant to conventional treatments [49]

PLoS One 10:e0122690 Kuniak E, Sklodowska M (2001) Ascorbate, glutathione and related enzymes in chloroplasts of tomato leaves infected by Botrytis cinerea

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Inhibition of phospholipase D 1/2 (PLD1/2) blocks ROS accumulation, iron metabolic disorders, and NLRP3 activation simultaneously, indicating that both processes share upstream regulatory nodes controlled by the PLD signaling pathway

We therefore injected whole-body Sxc-deficient mice with LPS (2 mg/kg body weight) 6 h before an IPGTT

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