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Twenty-seven patients from the high-concentration group were treated with immunotherapy, of them 26 (96%) received IV immunoglobulins (IVIg) in different treatment regimes

The size of these dense granules was larger (in the range of a few thousand angstroms) than previously reported for mitochondrial electron-dense clusters in mineralizing osteoid (ranging from 400 to 1000 angstroms) (Landis et al., 1977) The authors (Omelon et al., 2009) put together a hypothesis that apatite mineral dissolution in the osteoclast resorption zone increases the concentrations of free P i and Ca 2+