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Mn has been shown to modulate several TFs such as REST, YY1, Nrf2, TFEB, hypoxia-inducible factor 1 (HIF1), NF-B, and peroxisome proliferator-activated receptor gamma (PPAR-) in both in vitro and in vivo settings

[DOI] [PubMed] [Google Scholar] 21.Henriksen E.J

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In this setting, they acquire an exhausted phenotype but retain proinflammatory activity

Glutathione is important for natural killer cells natural killer sounds like something you dont want in your body, but in this case the natural killers are on your side, fighting off viruses and bacteria that try to attack you

These proteins can regulate the functions of host cells and support the bacteria in their effect of immune escape and colonization