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The SOD enzymes catalyze the disproportionation of superoxide (O2-) to produce hydrogen peroxide (H2O2), and the balance between copper and reactive oxygen species (ROS) is physiologically crucial (35,36)

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His folate plunged at the same time, and folate is also necessary to detoxify homocysteine

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Tryptophan metabolites, for their part, can reduce harmful behavior by gut flora (Li et al., 2014) and mitigate astrocyte activation to suppress neuroinflammatory responses in the central nervous system (Rothhammer et al., 2016)